Ameela polynucleotide product range — Ameela Eyes, Ameela Rejuvenation and Ameela Face preparations used at Pelle Aesthetics Hertford

Polynucleotide Injections · Hertford, Hertfordshire

Polynucleotides
Ameela® in Hertford

Next-generation skin regeneration using Ameela® polymerised PDRN — derived from salmon DNA, clinically proven to stimulate fibroblasts, restore collagen, and fundamentally renew skin at a cellular level. Doctor-administered by Dr Sabrina at Pelle Aesthetics.

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Rated 5.0 by 156 patients on Google. Pelle Aesthetics is Hertfordshire's top-rated doctor-led aesthetics clinic.

The Science

How polynucleotides
regenerate skin

Polynucleotides are the fundamental building blocks of DNA. In aesthetics, they are derived from highly purified salmon DNA — a source chosen for its exceptional biocompatibility with human skin and its extraordinary hydrating and regenerative properties.

When injected into the dermis, polynucleotides bind to growth factor receptors and directly stimulate fibroblasts — the cells responsible for producing your skin's collagen and elastin. This triggers genuine tissue regeneration at a cellular level: not a temporary fix, but a structural renewal of the skin from within.

Ameela® uses a unique polymerised PDRN formula, providing a longer tissue residence time and more sustained biological activity than standard polynucleotide products, for results that continue to improve over weeks and months.

At Pelle Aesthetics

Regenerative medicine,
precisely delivered

Polynucleotide treatments require precise anatomical knowledge and meticulous technique. At Pelle Aesthetics, every session is performed personally by Dr Sabrina using a micro cannula — an approach that significantly reduces discomfort and minimises the risk of bruising compared to standard needle injection.

Treatment begins with a full consultation and topical anaesthetic application. The procedure itself is typically completed within 30 minutes and results in immediate skin freshness, with progressive improvement over the weeks that follow.

Dr Sabrina

GMC-Registered GP  ·  Founder & Lead Clinician, Pelle Aesthetics
Hertford, Hertfordshire

The Ameela® Range

Three preparations,
one exceptional formula

Ameela®

Eyes

Periorbital — under-eye area

A specialised preparation specifically engineered for the delicate periorbital tissue. Ameela Eyes targets under-eye bags, dark circles, fine lines, and skin laxity around the eye contour — one of the most visible and challenging areas to treat.

  • Reduces under-eye bags and puffiness
  • Lightens dark circles by improving microcirculation
  • Firms and smooths periorbital fine lines
  • Gentle formulation for sensitive periorbital skin

Ameela®

Rejuvenation

Face, scalp, neck & hands

The most versatile preparation in the Ameela range. Designed for whole-face and body rejuvenation, it restores skin tone, elasticity, and deep hydration across multiple zones — including the neck, scalp, and hands where ageing is often most visible.

  • Comprehensive skin tone restoration
  • Improves elasticity and firmness
  • Deep hydration and plumping
  • Suitable for face, neck, décolletage, scalp, hands

Ameela®

Face

Full face — lines & tone

A comprehensive facial regeneration preparation targeting fine lines, skin texture, and uneven tone. Ameela Face delivers the full regenerative power of polymerised PDRN to the facial dermis, progressively renewing skin quality from within.

  • Reduces fine lines and superficial wrinkles
  • Evens skin tone and improves radiance
  • Stimulates collagen and elastin production
  • Suitable for all skin types including sensitive

Where We Treat

Treatment areas
across the face & body

👁

Under Eyes

Ameela Eyes

✦

Full Face

Ameela Face

○

Neck

Ameela Rejuvenation

◇

Décolletage

Ameela Rejuvenation

△

Hands

Ameela Rejuvenation

○

Scalp

Ameela Rejuvenation

△

Knees

Ameela Rejuvenation

◇

Abdomen

Ameela Rejuvenation

Your Treatment

What happens
during your session

01

Consultation & Skin Assessment

Every session begins with a detailed consultation. Dr Sabrina assesses your skin concerns, goals, and medical history to select the correct Ameela preparation and treatment protocol.

02

Skin Preparation & Anaesthetic

The treatment area is thoroughly cleansed and a topical anaesthetic cream is applied to ensure comfort. This is left to take effect before treatment begins.

03

Micro Cannula Delivery

Dr Sabrina uses a micro cannula technique to deliver the Ameela preparation precisely into the dermis. This minimises discomfort and significantly reduces the risk of bruising compared to needle injection.

04

Progressive Regeneration

Results develop progressively over 4–8 weeks as fibroblasts are stimulated to produce new collagen and elastin. Most patients require two sessions, 2–4 weeks apart, for optimal results.

Understanding Your Options

Polynucleotides
vs. Profhilo

This treatment

Polynucleotides (Ameela®)

  • PDRN derived from salmon DNA
  • Stimulates fibroblasts directly at cellular level
  • Genuine tissue regeneration — not just hydration
  • Three specialised preparations by zone
  • Particularly effective for under-eye and skin laxity
  • Also treats neck, scalp, hands, décolletage
  • Results build progressively over weeks

Alternative treatment

Profhilo

  • Ultra-pure hyaluronic acid
  • Stimulates collagen via osmotic action
  • Outstanding deep hydration and skin laxity
  • Single product for face and body
  • The gold standard for overall skin bio-remodelling
  • Also treats neck, hands, décolletage
  • Two sessions one month apart

Both are regenerative treatments that work beautifully alongside each other. Many patients combine polynucleotides and Profhilo for enhanced results — Dr Sabrina will advise on the optimal approach for your skin at consultation.

Guide Pricing

Investment in skin regeneration

Single Session

from £300

per session — Ameela Eyes, Face or Rejuvenation
bespoke plan at consultation

Recommended Course

2 Sessions

spaced 2–4 weeks apart for optimal results
course pricing available — ask at consultation

Maintenance

6–8 Months

results last 6–8 months — maintenance sessions recommended to sustain and build on results

At a Glance

Treatment summary

Treatment Time

~30 minutes

Return to Work

Immediate

Recovery

24 hours

Results

Progressive over 4–8 weeks

Sessions Needed

2 (2–4 wks apart)

Duration

6–8 months

Common Questions

Frequently asked questions

Polynucleotides are the fundamental building blocks of DNA. In aesthetics, they are derived from highly purified salmon DNA and are known for their exceptional hydrating and tissue-regenerating properties. When injected into the skin, they stimulate fibroblasts — the cells responsible for producing collagen and elastin — at a cellular level, triggering genuine skin regeneration.
Ameela® is a premium Italian polynucleotide brand using a unique polymerised PDRN formula. It comes in three specialised preparations — Eyes, Face, and Rejuvenation — each precisely formulated for different treatment zones and patient goals. The polymerised structure provides a longer tissue residence time and more sustained biological activity compared to standard PDRN products.
Polynucleotide treatment is suitable for all skin types. It is particularly effective for patients concerned with skin laxity, dullness, fine lines, under-eye hollowing or dark circles, dehydration, and loss of elasticity. It is not suitable for anyone with a fish or salmon allergy. Dr Sabrina will confirm suitability at consultation.
Topical anaesthetic cream is applied before treatment to maximise comfort. Dr Sabrina uses a micro cannula technique which minimises discomfort and reduces the risk of bruising significantly compared to standard needle injection. The procedure may cause some mild stinging but is generally very well-tolerated and typically completed within minutes.
Most patients require two sessions, spaced 2–4 weeks apart, for optimal results. Results are progressive — skin freshness is often noticed immediately, with the full regenerative effect developing over 4–8 weeks as new collagen and elastin is produced. Maintenance sessions every 6–8 months are recommended to sustain and build on results.
Both are bio-remodelling injectable treatments but they work through different mechanisms. Profhilo uses ultra-pure hyaluronic acid to deeply hydrate and stimulate collagen and elastin via osmotic action. Polynucleotides use PDRN to stimulate fibroblasts at a DNA level, triggering genuine tissue regeneration. Both are outstanding regenerative treatments — many patients use them together, and Dr Sabrina can advise the optimal combination for your skin at consultation.

Ready to Begin

Book your consultation with Dr Sabrina

Explore related treatments: Profhilo, Exosomes, Skinboosters, or Light Eyes Ultra. Dr Sabrina will advise the best regenerative protocol for your skin.

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Conveniently located in Hertford — accessible from St Albans, Welwyn Garden City, Ware, Hoddesdon, Potters Bar, Hatfield & North London.