How does the exosome treatment work at Pelle Aesthetics?

The treatment combines TargetCool Cryotherapy with topical PrimaCure E50 Exosomes, with or without microneedling. Cryotherapy prepares the skin and maximises exosome absorption.

Is exosome treatment suitable for sensitive skin?

Yes — suitable for all skin types including eczema, perioral dermatitis, and rosacea due to the powerful anti-inflammatory properties of marine exosomes.

Regenerative Aesthetics · Hertford, Hertfordshire

Exosome Skin
Treatment
in Hertford

The next frontier in skin regeneration. Marine-derived E50 exosomes combined with TargetCool Cryotherapy to reduce inflammation, stimulate collagen, and restore your skin's natural vitality — from within. Also available as a hair loss treatment.

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Close-up of a mature woman with healthy glowing skin alongside a DNA helix, representing exosome skin regeneration at Pelle Aesthetics Hertford

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GMC Registered Doctor

All Skin Types Suitable

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★★★★★

Rated 5.0 by 156 patients on Google. Pelle Aesthetics is Hertfordshire's top-rated doctor-led aesthetics clinic.

The Science

What are
exosomes?

Exosomes are microscopic, cell-derived messengers — tiny vesicles produced naturally by cells to communicate and transfer biological information. Rich in growth factors, peptides, messenger RNA, and microRNA, they play a fundamental role in tissue repair and regeneration.

In aesthetic medicine, exosomes represent a significant leap beyond traditional regenerative treatments. Where polynucleotides and growth factors work to stimulate individual cell functions, exosomes orchestrate a far wider repair response — triggering collagen and elastin synthesis, reducing chronic inflammation, and improving the overall cellular environment of the skin.

The E50 exosome formulation used at Pelle Aesthetics is marine-derived and biocompatible, meaning it works in harmony with your body's own healing systems.

Your Practitioner

Doctor-led,
always

Every exosome treatment at Pelle Aesthetics is administered personally by Dr Sabrina. Regenerative treatments are among the most nuanced in aesthetic medicine — understanding which patients will benefit most, how to combine exosomes with other modalities, and how to set realistic expectations requires genuine clinical knowledge.

Dr Sabrina takes a whole-skin approach, assessing your skin health and recommending the treatment programme most likely to deliver lasting, meaningful improvement.

Dr Sabrina

GMC-Registered GP · Founder & Lead Clinician, Pelle Aesthetics
Hertford, Hertfordshire

The Product

PrimaCure
E50 Exosomes

We use the PrimaCure E50 range — a clinically developed exosome formulation derived from marine sources. The range includes the E-50 Skin Booster (3.5ml), E50-H Solvent Ampoule, and E50-H Foam Applicator, allowing precise delivery of exosome actives both topically and in combination with microneedling.

Marine-derived exosomes are particularly well-suited to skin regeneration due to their natural biocompatibility and potent anti-inflammatory profile. Combined with TargetCool Cryotherapy, the treatment enhances absorption and maximises regenerative impact while keeping post-treatment redness to a minimum.

Why Choose Exosomes

What makes this treatment
different

Cutting-Edge Regenerative Technology

Exosomes work at a cellular signalling level that goes beyond traditional growth factor treatments — one of the most advanced offerings in Hertfordshire.

Suitable for All Skin Types

Including sensitive conditions such as eczema, perioral dermatitis, and rosacea — thanks to the powerful anti-inflammatory properties of marine exosomes.

Enhances Other Treatments

Exosomes amplify and accelerate the results of microneedling and laser when applied in combination. An ideal add-on or standalone regenerative course.

Minimal Downtime

Return to work immediately. Mild redness for up to 24 hours only — no extended recovery, no bandaging, no disruption to daily life.

Natural, Long-Lasting Results

Because exosomes stimulate your body's own regenerative processes, results continue developing over weeks and months — entirely natural, because they're produced by your own skin.

Skin & Hair Loss Applications

The E50 protocol can also be applied to the scalp to address hair thinning and loss, stimulating follicle regeneration and promoting new growth from within.

Two Applications

Skin rejuvenation
& hair loss treatment

Skin Treatment

Facial & Skin
Rejuvenation

Fine lines & wrinkles
Loss of firmness & elasticity
Uneven skin tone & texture
Acne scarring & enlarged pores
Chronic inflammation (rosacea, eczema)
Post-laser or microneedling recovery
Dull or fatigued complexion

Hair Treatment

Hair Loss &
Scalp Regeneration

Reduced shedding visible in 3 weeks
New hair growth from 2–3 months
Hair may continue growing over 12 months
Stimulates dormant follicles
Suitable for both men and women
Non-surgical, minimal downtime
2 sessions recommended, 2–4 weeks apart

Guide Pricing

Investment in your skin

Exosome Skin Treatment

£450

from · per session
course of 2 sessions recommended

Exosome Hair Treatment

£450

from · per session
course of 2 sessions recommended

Combined with Microneedling

Ask Us

pricing confirmed at consultation

At a Glance

Treatment summary

Treatment Time

~30 minutes

Return to Work

Immediate

Recovery

24 hours

First Results

48 hours

Optimal Results

4–6 weeks

Maintenance

Every 3–6 months

Common Questions

Frequently asked questions

What exactly are exosomes?

Exosomes are microscopic, cell-derived messengers — vesicles produced by cells to communicate biological signals. Rich in growth factors, peptides, and genetic material (mRNA and microRNA), they play a fundamental role in tissue repair and regeneration. In aesthetic medicine, they stimulate collagen and elastin production, reduce inflammation, and accelerate healing — offering regenerative results that go beyond traditional skincare actives.

How does the treatment work at Pelle Aesthetics?

The treatment combines TargetCool Cryotherapy with topical application of PrimaCure E50 Exosomes. Cryotherapy prepares the skin, opens channels, and reduces initial inflammation, maximising absorption of the exosome serum. Exosomes can be applied with or without microneedling depending on your skin's needs.

Is this suitable for sensitive skin?

Yes — suitable for all skin types, including eczema, perioral dermatitis, and rosacea. The anti-inflammatory properties of marine exosomes make this one of the few truly regenerative treatments that can be safely used in these conditions rather than aggravating them.

When will I see results?

Visible skin improvements begin as early as 48 hours post-treatment. Most significant results — improved firmness, texture, and skin quality — develop over 4–6 weeks as the body produces new collagen. For hair treatments, reduced shedding in as little as 3 weeks, with new growth appearing within 2–3 months.

How many sessions do I need?

Most patients achieve optimal results with two treatments spaced 2–4 weeks apart. Maintenance sessions every 3–6 months are recommended to sustain results. The exact programme will be tailored to your skin at consultation.

Is there any downtime?

Minimal. You can return to work immediately. Some mild redness may be present for up to 24 hours — a normal response that resolves quickly. The TargetCool Cryotherapy element helps minimise even this temporary redness.

How does exosome treatment compare to polynucleotides (PDRN)?

Both are regenerative treatments that stimulate the skin's own repair mechanisms. Polynucleotides provide a scaffold and growth stimulus for specific cell types. Exosomes work at a higher level — orchestrating a broader, multi-pathway regenerative response across many cell types simultaneously. For some patients, combining both offers the most comprehensive result. Dr Sabrina can advise on the best approach for your skin.

Exosome SkinTreatmentin Hertford

What areexosomes?

Doctor-led,always

What makes this treatmentdifferent